Recurring concern

Unreliable clinical guidance for transplant patients

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First reported 14 Apr 2014•Latest report 12 Nov 2024

Definition

What this concern includes

Includes failures of transplant-specific clinical guidance and protocols, including their development, completeness, accessibility, dissemination, staff understanding and application, across kidney, heart or other named transplant-care contexts where the guidance is intended to direct safe assessment, treatment or perioperative care.

Not included

  • Excludes generic clinical-guideline awareness or access failures where no transplant-specific guidance is involved.
  • Excludes failures in transplant treatment, monitoring, medication or surgery where no deficiency in transplant-specific guidance is identified.
  • Excludes organ-specific clinical guidance unrelated to transplantation, and non-transplant guidelines even when they concern similar clinical decisions.
  • Excludes generic staffing, training, communication or governance deficiencies unless they directly impair transplant-specific clinical guidance.
Reports
2

Distinct published reports

Individual concerns
2

A report can raise multiple concerns

Date range
2014–2024

First to latest report issue date

Stated actions
8

Described in published responses

Reports over time

Reports over time

Reports about this concern issued each year.

* 2026 is projected from reports observed to 7 Sep 2026.

Most frequent recipients

Most frequent recipients

Reports about this concern sent to each recipient.

Department of Health and Social Care1
George Eliot Hospital NHS Trust1
Medicines and Healthcare products Regulatory Agency1
NHS England1
The British Transplantation Society1
The Renal Association1
University Hospitals Coventry and Warwickshire NHS Trust1

Concerns and responses across reports

Only concerns grouped under this recurring concern are included. Select any concern, action or position to view the source wording.

  1. Coventry and Warwickshire

    AI-generated summary

    John Frederick Doyle · Prevention of Future Deaths report

    This summary was generated using AI from the published report. Please read the original report for the complete account.

    Report summary

    John Frederick Doyle, a kidney transplant recipient, was admitted with rectal bleeding and a persistent cough and was later diagnosed with a severe cytomegalovirus infection after delays in testing, diagnosis and transfer to specialist care. He deteriorated to multiple organ failure and died on 30 December 2023. Concerns included unclear arrangements for contacting specialist centres, sharing information, accessing renal guidance, initiating transfers and coordinating care between specialist and non-specialist hospitals.

    Read the report on judiciary.uk

    Source evidence

    How this individual concern was interpreted

    PFD Monitor created a concise, searchable interpretation from the report wording shown below.

    PFD Monitor interpretation

    Lack of consistent awareness of and access to kidney transplant care guidelines and protocols

    Wider context from the report

    “Concern 3: Accessibility to Renal Care Guidelines Non-specialist staff may experience varying levels of awareness or accessibility to guidelines and protocols for treating kidney transplant patients. This could lead to a misunderstanding of the significance and urgency of the actions recommended by specialist renal hospitals. ”

    Source location

    John Frederick Doyle · Prevention of Future Deaths report
    Page 4 · concerns

    Open source report

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Finalise, agree, and cascade shared guidelines for managing acutely unwell kidney-transplant inpatients.

    Verbatim wording from the response

    “As you are aware from the evidence of the medical witnesses at the inquest on 8 November 2024, the renal team at UHCW have been developing guidelines to assist George Eliot Hospital (GEH), a non-renal specialist hospital, in the management of acutely unwell kidney transplant renal inpatients. We are pleased to report that these guidelines have been finalised and agreed between the Trusts and we enclose a copy.”

    Source location

    Response 1 from Coventry and Warwickshire Partnership Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Place the agreed renal-care guidelines on the Trust intranet after governance ratification.

    Verbatim wording from the response

    “These guidelines have been shared and cascaded within the respective clinical teams which includes discussion as the Trust’s Renal Quality Improvement and Patient Safety meeting (QIPS). Once ratified through the usual governance processes these guidelines will be placed on the Trust’s intranet to be accessible to all staff.”

    Source location

    Response 1 from Coventry and Warwickshire Partnership Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Complete ratification and upload the renal management guidelines to the Trust intranet.

    Verbatim wording from the response

    “The Trust has now received management guidelines from the Renal Team at UHCW and below is a table showing what actions the Trust has taken to embed the information received.”

    Source location

    Response 1 from George Eliot Hospital NHS Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Produce laminated quick-reference guidance for managing acutely unwell kidney transplant recipients.

    Verbatim wording from the response

    “Description | Action Taken New guidelines to be made easily accessible on the Trust’s intranet | Guidelines have been developed and are currently going through the Trust’s ratification process prior to uploading on to the Trust’s intranet. Quick reference guidelines for management of acute unwell kidney transplant recipients have been produced (a laminated poster will be displayed in clinical areas) | Posters have been shared for dissemination with the Directorate Governance Leads on the 12 December 2024. These will be discussed at the Directorate Governance Meeting. Guidelines to be discussed at the daily doctors briefing | Information on the new guidelines and how to access them formed part of the daily brief for wards and departments from the 16 to the 20 December 2024. On the 17 December the guidelines and quick reference was e-mailed to all doctors and consultants.”

    Source location

    Response 1 from George Eliot Hospital NHS Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Disseminate the renal guidelines and quick-reference materials to Directorate Governance Leads, doctors, consultants and relevant clinical staff.

    Verbatim wording from the response

    “Description | Action Taken New guidelines to be made easily accessible on the Trust’s intranet | Guidelines have been developed and are currently going through the Trust’s ratification process prior to uploading on to the Trust’s intranet. Quick reference guidelines for management of acute unwell kidney transplant recipients have been produced (a laminated poster will be displayed in clinical areas) | Posters have been shared for dissemination with the Directorate Governance Leads on the 12 December 2024. These will be discussed at the Directorate Governance Meeting. Guidelines to be discussed at the daily doctors briefing | Information on the new guidelines and how to access them formed part of the daily brief for wards and departments from the 16 to the 20 December 2024. On the 17 December the guidelines and quick reference was e-mailed to all doctors and consultants.”

    Source location

    Response 1 from George Eliot Hospital NHS Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Discuss the new renal guidance at Directorate Governance Meetings and Trust-wide Governance meetings.

    Verbatim wording from the response

    “Description | Action Taken New guidelines to be made easily accessible on the Trust’s intranet | Guidelines have been developed and are currently going through the Trust’s ratification process prior to uploading on to the Trust’s intranet. Quick reference guidelines for management of acute unwell kidney transplant recipients have been produced (a laminated poster will be displayed in clinical areas) | Posters have been shared for dissemination with the Directorate Governance Leads on the 12 December 2024. These will be discussed at the Directorate Governance Meeting. Guidelines to be discussed at the daily doctors briefing | Information on the new guidelines and how to access them formed part of the daily brief for wards and departments from the 16 to the 20 December 2024. On the 17 December the guidelines and quick reference was e-mailed to all doctors and consultants.”

    Source location

    Response 1 from George Eliot Hospital NHS Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Reiterate the renal guidance at the Doctors Grand Round.

    Verbatim wording from the response

    “This will be reiterated at the Doctors Grand Round. To be discussed at all Trust wide Governance meetings for them to share with all consultants/relevant members of staff | Shared with all Directorate Governance Leads on the 12 December 2024 for dissemination.”

    Source location

    Response 1 from George Eliot Hospital NHS Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent action was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Display laminated renal quick-reference posters across clinical areas and the Trust.

    Verbatim wording from the response

    “Description | Action Taken New guidelines to be made easily accessible on the Trust’s intranet | Guidelines have been developed and are currently going through the Trust’s ratification process prior to uploading on to the Trust’s intranet. Quick reference guidelines for management of acute unwell kidney transplant recipients have been produced (a laminated poster will be displayed in clinical areas) | Posters have been shared for dissemination with the Directorate Governance Leads on the 12 December 2024. These will be discussed at the Directorate Governance Meeting. Guidelines to be discussed at the daily doctors briefing | Information on the new guidelines and how to access them formed part of the daily brief for wards and departments from the 16 to the 20 December 2024. On the 17 December the guidelines and quick reference was e-mailed to all doctors and consultants.”

    Source location

    Response 1 from George Eliot Hospital NHS Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent position was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Specialist-led care is considered sufficient, so clinicians should not necessarily need to refer to renal care guidelines.

    Verbatim wording from the response

    “• As access to Guidelines could lead to a misunderstanding of the significance and urgency of required actions; the critical action in this case would be to contact the Specialist Centre.”

    Source location

    Response from UKKA and BTS
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent position was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Oversight of delegated renal medicine services rests with individual Integrated Care Boards, including Coventry and Warwickshire ICB.

    Verbatim wording from the response

    “Renal medicine is a specialist service that is delegated to individual Integrated Care Boards. My regional colleagues in the Midlands have been sighted on your Report, and have shared it with Coventry and Warwickshire ICB, for the appropriate oversight.”

    Source location

    Response from NHS England
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent position was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Providers involved in the care should respond to concerns about local arrangements and processes, rather than NHS England.

    Verbatim wording from the response

    “I note that your Report has also been sent to University Hospitals Coventry and Warwickshire NHS Trust (UHCW) and George Eliot Hospital NHS Trust (GEH). It is appropriate that the providers involved in John’s care respond to the Coroner regarding the concerns raised which relate to local arrangements and process. NHS England has asked to be sighted on their responses once these are in due course and whether any further actions are required from our Specialised Commissioning Teams.”

    Source location

    Response from NHS England
    Page 2 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent position was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    The agreed guidelines, service-level agreement and related processes are considered sufficient to address the six concerns.

    Verbatim wording from the response

    “As you are aware from the evidence of the medical witnesses at the inquest on 8 November 2024, the renal team at UHCW have been developing guidelines to assist George Eliot Hospital (GEH), a non-renal specialist hospital, in the management of acutely unwell kidney transplant renal inpatients. We are pleased to report that these guidelines have been finalised and agreed between the Trusts and we enclose a copy.”

    Source location

    Response 1 from Coventry and Warwickshire Partnership Trust
    Page 1 · response
    Published 12 November 2024

    Open published response

    Source evidence

    How this respondent position was interpreted

    PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

    PFD Monitor interpretation

    Specialist renal care should rely on direct specialist contact rather than universal guideline access, because guidelines may cause misunderstanding of urgency.

    Verbatim wording from the response

    “• As access to Guidelines could lead to a misunderstanding of the significance and urgency of required actions; the critical action in this case would be to contact the Specialist Centre”

    Source location

    Response 2 from Coventry and Warwickshire Partnership Trust
    Page 2 · response
    Published 12 November 2024

    Open published response
  2. Manchester West

    AI-generated summary

    Paul Michael Ashton · Prevention of Future Deaths report

    This summary was generated using AI from the published report. Please read the original report for the complete account.

    Report summary

    Paul Michael Ashton died during a right knee arthroscopy under general anaesthesia after suffering a cardiac arrest. The concerns included the absence of hospital protocols for the perioperative management of heart-transplanted patients undergoing non-cardiac surgery, and issues concerning the availability and use of Isoprenaline during resuscitation.

    Read the report on judiciary.uk

    Source evidence

    How this individual concern was interpreted

    PFD Monitor created a concise, searchable interpretation from the report wording shown below.

    PFD Monitor interpretation

    Lack of protocols and guidelines for perioperative management of heart transplant patients undergoing non-cardiac surgery

    Wider context from the report

    “(2) I have concerns with regard to the following:- i. The absence of protocols and guidelines in Hospitals dealing with the perioperative management of heart transplanted patients due to undergo or undergoing non cardiac surgery. Such a protocol or guidelines could summarise issues that need to be considered when assessing and caring for a patient with a transplanted heart and the elements of such protocol or guidelines could include the following: a) Pre-operative assessment b) Liaising with the transplant unit the patient is under for follow up. c) Guidance on risk d) Benefit discussion with the patient and consent process e) Perioperative management (anaesthetic technique(s), monitoring, drugs and their doses and fluid balance etc.) f) Postoperative care g) Strategies for perioperative complications including resuscitation procedures and the use of Isoprenaline. ii. The source, availability and the use of Isoprenaline in Hospitals and by health professionals in relation to the resuscitation of heart transplanted patients. Isoprenaline is a drug that is considered to be the best anti-bradycardic agent in denervated or transplanted patients and disappeared from the United Kingdom formulary about 10 years ago. It is therefore assumed that it is not available anymore and that Adrenaline is the only drug effective in bradycardia in denervated hearts. ”

    Source location

    Paul Michael Ashton · Prevention of Future Deaths report
    Page 3 · concerns

    Open source report
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Data last updated 7 September 2026