Investigation and inquest
On 04 February 2026 I commenced an investigation and opened an inquest into the death of Jack Horace BURTON aged 29. The investigation concluded at the end of the inquest on 14 May 2026. The conclusion of the inquest was that:
Narrative Conclusion - Jack Horace Burton died on 7 October 2025 at 76 Moorland Road, Scarborough, North Yorkshire of Clozapine toxicity. Mr Burton had been prescribed Clozapine for schizophrenia and he was a smoker, who had been regularly advised that any cessation of smoking would increase Clozapine levels. Mr Burton stopped smoking tobacco on or before 4 October 2025. On the evidence it is likely that this led to a fatal increase in Clozapine blood levels.
Circumstances of the death
The deceased resided in Worcester and was under primary and secondary healthcare services in that area. He had a diagnosis of paranoid schizophrenia and was prescribed Clozapine by his community psychiatrist. He died while on holiday in North Yorkshire and the results of the post-mortem and toxicology indicate his death was due to Clozapine toxicity. His sister confirmed that Jack was a heavy smoker and was taking 525mg Clozapine nightly as prescribed, which is the correct dose when he is smoking, however whilst they have been on holiday he did not smoke . If he had stopped or reduced his smoking he should have informed his psychiatrist to reduce the amount of Clozapine he was taking , as this could cause seizures.
Coroner’s concerns
1. There were inconsistent accounts provided to me by two consultant psychiatrists, about the relevance of reduction in smoking, rather than cessation of smoking, attributable to there being no guidance available to doctors on this issue.
2. The evidence revealed that there is no guidance on any standardised practice available to practitioners relating to asking questions and recording answers given when discussing possible symptoms of side effects of the medication. Practitioners can therefore make no record if no information is provided, which does not indicate whether questions were asked.