Investigation and inquest
On 2/10/25, an investigation was commenced into the death of Tung Thanh Tran, aged 41 years. I heard the subsequent inquest on 13/3/26.
The medical cause of death was determined to be:
1.a. Acute liver failure
1.b. Sepsis (unknown source)
1.c. Hepatitis B reactivation owing to cessation of medication
2. Immunosuppression for renal transplantation
Mr Tran died at Royal Free Hospital, London on 12/9/25
Inquest Conclusion
Mr Tran died of complications arising from reactivation of a viral illness, which arose from inadvertent discontinuation of necessary medical treatment.
Circumstances of the death
Mr Tran had a background history of renal transplant in 2013 and was diagnosed with chronic hepatitis B as part of this process. After a period of disengagement from services, Mr Tran was discharged from hepatology but continued to receive viral reactivation prophylaxis (Entecavir) from renal transplant services.
Supply of medication changed to home delivery in early 2025 but the Entecavir was inadvertently discontinued, as there was a presumption that hepatology would continue to prescribe this. Mr Tran appears to have understood this to have been an intentional change of his medication.
He attended his local hospital in August 2025 with signs of acute liver disease from reactivation of hepatitis B and was transferred to the Royal Free Hospital. He was too unwell to be considered for liver transplant and sadly died on 12 September 2025.
Coroner’s concerns
1. There is a lack of national guidance regarding which services should be responsible for the monitoring and prescribing in relation to hepatitis B reactivation prevention; (concern directed to BASL)
2. There is a large population of patients who are found to have hepatitis B infection through opt-out screening in Emergency Departments but there is a lack of specialised commissioning to maintain subsequent engagement with services. I heard that this differs from the position with regards to hepatitis C and HIV services, even though these patient populations are smaller (concern directed to UKHSA)