PFD report

Nature Barr · Prevention of Future Deaths report

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Issued 15 May 2017•Inner North London

Report record

Published report and response evidence

This page connects the concerns raised in this report with statements found in recipients’ published responses. A link shows a clear evidence connection; it does not assign responsibility.

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Concerns
1

Raised in this report

Recipients
1

Named on the report

Responses found
3

Of 1 recipient

Stated actions
17

Described in responses

Recipients and published responses

Source document

Full report text

This is the full text from the original published report.

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Concerns and recipient responses

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Report evidence summary

Concerns raised1

  1. Lack of specific evidence that steps are being taken to address the described risk
Responses linked to these concerns

Each statement is shown once, even when linked to more than one concern.

Actions described in response An action is something a recipient says it has done, is doing, or plans to do in response to a concern raised.15

  1. Action

    Contribute expertise to international drug-control and global monitoring bodies addressing new psychoactive substances.

    Stated by Alere ForensicsStated completedThe respondent said that this action was complete when they made their response on 16 August 2017.
  2. Action

    Participate in UK and European early warning systems for new psychoactive substances.

    Stated by Alere ForensicsStated completedThe respondent said that this action was complete when they made their response on 16 August 2017.
  3. Action

    Attend and present at national and international scientific meetings and publish on new psychoactive substances.

    Stated by Alere ForensicsStated completedThe respondent said that this action was complete when they made their response on 16 August 2017.

Respondent positions A position is what a recipient says about a concern when it does not describe a specific action.2

  1. Position

    Many toxicology organisations cannot implement multi-technique NPS testing because it requires time and investment unavailable under cost and turnaround pressures.

    Stated by Alere ForensicsUnable to actThe respondent said that a constraint prevented them from taking the relevant action.

Source evidence

How this individual concern was interpreted

PFD Monitor created a concise, searchable interpretation from the report wording shown below. Response links show a clear evidence connection; they do not assign responsibility.

PFD Monitor interpretation

Lack of specific evidence that steps are being taken to address the described risk

Wider context from the report

“In particular, I heard that positive steps have been taken by the NHS Trust involved in Mr Barr’s care to form a partnership with the University of Hertfordshire, in order to facilitate research into this area. At the inquest into Mr Barr’s death there was no specific evidence adduced which reassured me that steps are being taken to address the risk described above. However, I believe that the Drug Misuse and Novel Psychoactive Substance Unit at the University of Hertfordshire may be able to provide such evidence. This is the reason I judged that my statutory duty to write this report was engaged. ”

Is this part of a recurring concern?

No recurring-concern membership is currently published.

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Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Contribute expertise to international drug-control and global monitoring bodies addressing new psychoactive substances.

Verbatim wording from the response

“For our organisation in particular, we regularly attend and present at such meetings as well publishing on the topic of NPS (see list of publications on our website) and importantly are also actively engaged in the UK and European Early Warning Systems for NPS. I am also personally a Member of the Expert Committee for Drugs and Drug Dependence (ECDD) at the World Health Organisation that prioritises NPS for assessment for international drug control as well as working directly with the United Nations Office on Drugs and Crime (UNODC) that monitor the situation worldwide. This has resulted from my many years involvement in the investigation and identification of NPS (sometimes for the first time in the UK, Europe and the world) which has resulted from a significant time investment and determined effort in such investigations on the back of clinical and post-mortem toxicology casework.”

Source location

Howard-Jeffers-Response3
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Participate in UK and European early warning systems for new psychoactive substances.

Verbatim wording from the response

“For our organisation in particular, we regularly attend and present at such meetings as well publishing on the topic of NPS (see list of publications on our website) and importantly are also actively engaged in the UK and European Early Warning Systems for NPS. I am also personally a Member of the Expert Committee for Drugs and Drug Dependence (ECDD) at the World Health Organisation that prioritises NPS for assessment for international drug control as well as working directly with the United Nations Office on Drugs and Crime (UNODC) that monitor the situation worldwide. This has resulted from my many years involvement in the investigation and identification of NPS (sometimes for the first time in the UK, Europe and the world) which has resulted from a significant time investment and determined effort in such investigations on the back of clinical and post-mortem toxicology casework.”

Source location

Howard-Jeffers-Response3
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Attend and present at national and international scientific meetings and publish on new psychoactive substances.

Verbatim wording from the response

“The toxicology community is aware of the challenges and problems involved in NPS and there is a concerted effort to first ensure they are aware of the various drugs of concern, whether this is through awareness of the scientific literature and/or attendance at scientific meetings (both national and international) where NPS are invariably discussed, not least at the UK & Ireland Association of Forensic Toxicologists (UKIAFT) where Dr Paterson and myself are Chair and Vice-Chair, respectively. Within these meetings (especially internationally) analytical methodologies are presented and published but of course it is the duty of the toxicologists and organisations to assess whether they have the necessary opportunity to replicate such work.”

Source location

Howard-Jeffers-Response3
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Provide new psychoactive substance and toxicology training for coroners, coroners’ officers, pathologists and autopsy practitioners.

Verbatim wording from the response

“We also work with Liverpool John Moores’s University to obtain synthesised or characterised reference material of NPS that are newly on the market or have yet to become fully commercialised. This is subsequently coupled with publications to allow other laboratories to detect and identify such substances. This particular approach has been very successful in many cases on behalf of HM Coroners and the Police, with us being able to pre-emptively identify NPS that have had a positive impact on the investigation; including cause of death and driving under the influence in particular. We also provide training for stakeholders (HM Coroners, Coroners’ Officers, Pathologists and APTs) in relation to current drugs and toxicology.”

Source location

Howard-Jeffers-Response3
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Work with a university to obtain reference materials for newly marketed substances and publish information enabling other laboratories to detect and identify them.

Verbatim wording from the response

“We also work with Liverpool John Moores’s University to obtain synthesised or characterised reference material of NPS that are newly on the market or have yet to become fully commercialised. This is subsequently coupled with publications to allow other laboratories to detect and identify such substances. This particular approach has been very successful in many cases on behalf of HM Coroners and the Police, with us being able to pre-emptively identify NPS that have had a positive impact on the investigation; including cause of death and driving under the influence in particular. We also provide training for stakeholders (HM Coroners, Coroners’ Officers, Pathologists and APTs) in relation to current drugs and toxicology.”

Source location

Howard-Jeffers-Response3
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Host university MSc studentships for projects researching analytical methods and substance instability.

Verbatim wording from the response

“Even for ourselves there are still challenges such as ensuring methodologies are kept up-to-date and potential substance instability is researched and understood; to this end we regularly accommodate university MSc studentships (including King’s College London and the University of Birmingham) for short-term projects to do this.”

Source location

Howard-Jeffers-Response3
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Research handheld Raman spectroscopy and mixture-analysis algorithms to improve rapid in-field identification of NPS and reduce reliance on forensic laboratory testing.

Verbatim wording from the response

“Our efforts are also focused to improve in-field methods of NPS identification in products using analytical approaches (led by Dr Jacqueline Stair). The main approach we are currently researching in handheld Raman spectroscopy which allows the identification of key molecular scaffolds via the scattering of light. This tool is to enable the quick identification of NPS at borders, from seizures, or from individuals. Due to the > 650 NPS that exists, Raman spectroscopy can differentiate between closely related NPS analogues which can vastly reduce the number of substances sent to forensic labs for full analytical testing, which can be costly and time-consuming. A particular challenge is that NPS products are often available as complicated mixtures of NPS, adulterants, and cutting agents.”

Source location

Howard-Jeffers-Response2
Page 2 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Collect data on NPS effects among people admitted to Highgate Mental Health Centre.

Verbatim wording from the response

“Specific actions taken to address the concern: Very little is known of the effect of NPS in individuals with mental health conditions. Our University of Hertfordshire (UH)-based NPS Unit has started to collect data on the effect of the NPS in individuals admitted in the Highgate Mental Health Centre.”

Source location

Howard-Jeffers-Response2
Page 2 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Conduct a collaborative study to generate evidence for policies controlling and reducing harms from NPS among vulnerable individuals.

Verbatim wording from the response

“This particular project is being carried out in collaboration with two Highgate Mental Health Centre psychiatrists who have also enrolled for a PhD with our University (supervisor: Dr Ornella Corazza). The aim of their study is to gather new information on the effect of the NPS among vulnerable individuals, but also to develop evidence-based policies that will help to control and reduce the damage caused by these compounds.”

Source location

Howard-Jeffers-Response2
Page 2 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Research and biologically test predicted next-generation NPS chemical scaffolds, incorporating active compounds’ spectral properties into identification models.

Verbatim wording from the response

“In order to compliment and extend the work carried out to systematically classify existing NPS, Dr Stewart Kirton, Dr Jacqueline Stair and Dr Suzanne Fergus are leading research into predicting the next generation of chemical scaffolds that could be exploited by those who synthesize and distribute NPS. One PhD student (Michelle Botha) has used computers to identify a series of commercially available compounds that have the potential to bind to the CB1 receptor, but crucially are significantly different with respect to their chemical structures from any of the identified synthetic cannabinoids. Currently, biological testing is underway to establish if the activity predicted in silico is apparent in vitro/in vivo. Where biological activity exists, the spectral properties of the active compounds will be fed into the computational models that have previously been described.”

Source location

Howard-Jeffers-Response2
Page 4 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Develop and deliver NPS categorisation training for police officers and prison healthcare professionals to support treatment decisions.

Verbatim wording from the response

“She is also leading on a two-fold study: 1) to train and educate police officers on the use of handheld Raman instruments which could be employed on road-sides as well as in prisons for the identification of solid samples confiscated from prisoners and 2) to train and educate police officers and healthcare professionals who work in prisons on NPS and their categorization, which may potentially enhance the management of NPS use and assist in treatment decision-making. Her work is currently exploring developing undergraduate pharmacy curricula on NPS, which can be piloted nationally.”

Source location

Howard-Jeffers-Response2
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Complete research developing spectroscopic and chemometric approaches, spectral libraries and databases for accurate NPS identification by non-experts.

Verbatim wording from the response

“As an extension of this work, Dr Amira Guirguis recently completed a PhD (supervised by Dr Jacqueline Stair, Dr Stewart Kirton and Dr Suzanne Fergus) on the ‘identification of NPS using spectroscopic and chemometric approaches’. Her work examined the issues surrounding the appropriate selection of analytical conditions and instrumentation for the detection of NPS; a scientifically-robust approach to construct compound libraries that have relevance to ‘in-field’ analysis and data analytical science that examined approaches that can be employed to develop accurate NPS identification algorithms from spectroscopic information for use by non-experts.”

Source location

Howard-Jeffers-Response2
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Collaborate with French psychiatrists and addiction specialists to design a clinical tool for efficient NPS identification.

Verbatim wording from the response

“Dr Guirguis is also leading on potential collaborations with the Royal Pharmaceutical Society (RPS), consultant psychiatrists, addiction specialists, general community pharmacists, mental health pharmacists and mental health nurses in the UK to assess the baseline knowledge on NPS and the design of education and training courses on NPS targeting healthcare professionals. Future work over the next year will include collaborations with French psychiatrists and addiction specialists to design a tool that clinicians can use for the efficient identification of NPS.”

Source location

Howard-Jeffers-Response2
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Lead collaborations with healthcare and pharmaceutical professionals to assess NPS knowledge and design education and training courses.

Verbatim wording from the response

“Dr Guirguis is also leading on potential collaborations with the Royal Pharmaceutical Society (RPS), consultant psychiatrists, addiction specialists, general community pharmacists, mental health pharmacists and mental health nurses in the UK to assess the baseline knowledge on NPS and the design of education and training courses on NPS targeting healthcare professionals. Future work over the next year will include collaborations with French psychiatrists and addiction specialists to design a tool that clinicians can use for the efficient identification of NPS.”

Source location

Howard-Jeffers-Response2
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Develop and deliver training for police officers on using handheld Raman instruments to identify confiscated solid samples.

Verbatim wording from the response

“She is also leading on a two-fold study: 1) to train and educate police officers on the use of handheld Raman instruments which could be employed on road-sides as well as in prisons for the identification of solid samples confiscated from prisoners and 2) to train and educate police officers and healthcare professionals who work in prisons on NPS and their categorization, which may potentially enhance the management of NPS use and assist in treatment decision-making. Her work is currently exploring developing undergraduate pharmacy curricula on NPS, which can be piloted nationally.”

Source location

Howard-Jeffers-Response2
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent position was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Many toxicology organisations cannot implement multi-technique NPS testing because it requires time and investment unavailable under cost and turnaround pressures.

Verbatim wording from the response

“Clearly the inquest heard evidence of the challenging nature of NPS and their analysis. This is due to a number of things but is largely in part due to the changing chemistries, sometimes potent nature leading to very low concentrations, lack of reference material to enable “pro-active” method optimisation and potential instability of such substances in biological fluid – especially post-mortem samples. This is not helped by the variable analytical methods employed by toxicology organisations as there is no one “gold standard” technique or instrument as a multi-technique approach is the best option and this requires time and investment, that is not possible for all or many organisations or palatable in the current climate of lower costs and quicker turnaround time for analysis. So you raise an appropriate concern in that how is this being addressed by the toxicological community.”

Source location

Howard-Jeffers-Response3
Page 2 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent position was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

The unit will not develop biological-matrix NPS identification techniques because its expertise does not extend to this analysis.

Verbatim wording from the response

“We hope that our response demonstrates the actions that are being taken here in the Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit at the University of Hertfordshire to address the concerns around the real and significant dangers posed by the abuse of NPS. As you can see our approaches to tackling the problem are multi-faceted and extend from physical science and informatics, through medicinal chemistry and biological evaluation to clinical guidance and epidemiology. However, it is important to be clear that at this time we have no plans to develop techniques for the identification of NPS and their metabolites from biological matrices (e.g. blood and urine). The expertise of the members of the group does not extend to this type of biological analysis, and we feel others are better placed to address this issue.”

Source location

Howard-Jeffers-Response2
Page 4 · response
Published 16 August 2017

Open published response

Other statements in published responses

These actions and other statements could not be clearly connected to one concern in this report.

Recipient-stated actions An action is something a recipient says it has done, is doing, or plans to do in response to a concern raised.2

  1. 1

    Explore development of undergraduate pharmacy curricula on NPS for potential national piloting.

    Stated by University of HertfordshireStated in progressThe respondent said that this action was in progress when they made their response on 16 August 2017.
  2. 2

    Seek funding to extend predictive NPS scaffold research beyond synthetic cannabinoids.

    Stated by University of HertfordshireStated plannedThe respondent said that this action was planned when they made their response on 16 August 2017.

Recipient positions A position is what a recipient says about a concern when they do not describe a specific action.1

  1. 1

    No further action is proposed because NPS analysis is limited by compound variety, potency, funding, unavailable standards and insufficient pharmacological data.

    Stated by Imperial College LondonUnable to actThe respondent said that a constraint prevented them from taking the relevant action.

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Explore development of undergraduate pharmacy curricula on NPS for potential national piloting.

Verbatim wording from the response

“She is also leading on a two-fold study: 1) to train and educate police officers on the use of handheld Raman instruments which could be employed on road-sides as well as in prisons for the identification of solid samples confiscated from prisoners and 2) to train and educate police officers and healthcare professionals who work in prisons on NPS and their categorization, which may potentially enhance the management of NPS use and assist in treatment decision-making. Her work is currently exploring developing undergraduate pharmacy curricula on NPS, which can be piloted nationally.”

Source location

Howard-Jeffers-Response2
Page 3 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Seek funding to extend predictive NPS scaffold research beyond synthetic cannabinoids.

Verbatim wording from the response

“For the first time, this will provide a technology capable of identifying and classifying molecular scaffolds prior to them appearing on the market. Funding will be sought to extend the scope of this research into other classes of NPS beyond that of the synthetic cannabinoids.”

Source location

Howard-Jeffers-Response2
Page 4 · response
Published 16 August 2017

Open published response

Source evidence

How this respondent position was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

No further action is proposed because NPS analysis is limited by compound variety, potency, funding, unavailable standards and insufficient pharmacological data.

Verbatim wording from the response

“Conclusion Analysis of NPSs is limited and challenging because of the number of compounds available, their potency, lack of funding, lack of standards and lack of pharmacological data. Therefore no action is proposed.”

Source location

Howard-Jeffers-Response
Page 2 · response
Published 16 August 2017

Open published response
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Information checked against the published report and official responses · Data reviewed 7 Sep 2026 · About data quality and limitations

Official responses located
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Data last updated 7 September 2026