PFD report

Lee Derek Jamie ADAMS · Prevention of Future Deaths report

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Issued 20 Mar 2025•Inner South London

Report record

Published report and response evidence

This page connects the concerns raised in this report with statements found in recipients’ published responses. A link shows a clear evidence connection; it does not assign responsibility.

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Concerns
3

Raised in this report

Recipients
1

Named on the report

Responses found
1

Of 1 recipient

Stated actions
1

Described in responses

Source document

Full report text

This is the full text from the original published report.

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Concerns and recipient responses

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Report evidence summary

Concerns raised3

  1. Rapid absorption and dose-related effects of propranolol
  2. High toxicity of propranolol at small doses
  3. Lack of a specific antidote and reliance on hospital-based supportive treatment for propranolol overdose
Responses linked to these concerns

Each statement is shown once, even when linked to more than one concern.

Actions described in response An action is something a recipient says it has done, is doing, or plans to do in response to a concern raised.1

  1. Action

    Evaluate whether a Drug Safety Update article would increase doctors’ awareness of propranolol overdose risks.

    Stated by Medicines and Healthcare products Regulatory AgencyStated in progressThe respondent said that this action was in progress when they made their response on 26 March 2026.

Source evidence

How this individual concern was interpreted

PFD Monitor created a concise, searchable interpretation from the report wording shown below. Response links show a clear evidence connection; they do not assign responsibility.

PFD Monitor interpretation

Rapid absorption and dose-related effects of propranolol

Wider context from the report

“(1) Propranolol is absorbed quickly (the court heard within 30-60 minutes of ingestion) and dose related. (2) As a drug it is very effective in what it is prescribed for being used for, for example, in the community to treat hypertension, anxiety and migraines. BUT unfortunately, it is highly toxic at even small doses. (3) There is no specific anti-dote to a propranolol overdose, the only form of treatment is supportive and therefore hospital based. (4) Doctors and specifically GPs should be aware of the consequences, at relatively small doses, of excess propranolol ingestion; especially when there is no specific anti-dote and treatment is restricted to supportive measures only. ”

Is this part of a recurring concern?

No recurring-concern membership is currently published.

Open source report

Source evidence

How this individual concern was interpreted

PFD Monitor created a concise, searchable interpretation from the report wording shown below. Response links show a clear evidence connection; they do not assign responsibility.

PFD Monitor interpretation

High toxicity of propranolol at small doses

Wider context from the report

“(1) Propranolol is absorbed quickly (the court heard within 30-60 minutes of ingestion) and dose related. (2) As a drug it is very effective in what it is prescribed for being used for, for example, in the community to treat hypertension, anxiety and migraines. BUT unfortunately, it is highly toxic at even small doses. (3) There is no specific anti-dote to a propranolol overdose, the only form of treatment is supportive and therefore hospital based. (4) Doctors and specifically GPs should be aware of the consequences, at relatively small doses, of excess propranolol ingestion; especially when there is no specific anti-dote and treatment is restricted to supportive measures only. ”

Is this part of a recurring concern?

No recurring-concern membership is currently published.

Open source report

Source evidence

How this individual concern was interpreted

PFD Monitor created a concise, searchable interpretation from the report wording shown below. Response links show a clear evidence connection; they do not assign responsibility.

PFD Monitor interpretation

Lack of a specific antidote and reliance on hospital-based supportive treatment for propranolol overdose

Wider context from the report

“(1) Propranolol is absorbed quickly (the court heard within 30-60 minutes of ingestion) and dose related. (2) As a drug it is very effective in what it is prescribed for being used for, for example, in the community to treat hypertension, anxiety and migraines. BUT unfortunately, it is highly toxic at even small doses. (3) There is no specific anti-dote to a propranolol overdose, the only form of treatment is supportive and therefore hospital based. (4) Doctors and specifically GPs should be aware of the consequences, at relatively small doses, of excess propranolol ingestion; especially when there is no specific anti-dote and treatment is restricted to supportive measures only. ”

Is this part of a recurring concern?

No recurring-concern membership is currently published.

Open source report

Source evidence

How this respondent action was interpreted

PFD Monitor created a concise, searchable interpretation from the published response wording shown below.

PFD Monitor interpretation

Evaluate whether a Drug Safety Update article would increase doctors’ awareness of propranolol overdose risks.

Verbatim wording from the response

“In response to your matter of concern that ‘Doctors and specifically GPs should be aware of the consequences, at relatively small doses, of excess propranolol ingestion; especially when there is no specific anti-dote and treatment is restricted to supportive measures only’ we are currently evaluating whether an article in the MHRA’s safety bulletin for healthcare professionals ‘Drug Safety Update’ would be an effective way to further increase the awareness of doctors of the risks of propranolol in overdose.”

Source location

Response from Medicines and Healthcare products Regulatory Agency
Page 2 · response
Published 26 March 2026

Open published response
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Information checked against the published report and official responses · Data reviewed 7 Sep 2026 · About data quality and limitations

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Data last updated 7 September 2026