This page connects the concerns raised in this report with statements found in recipients’ published responses. A link shows a clear evidence connection; it does not assign responsibility.
On 18 June 2024 an investigation was commenced into the death of Paolino AMICO, aged 63 years. The investigation concluded at the inquest on 3 November 2025. The conclusion of the inquest was a Narrative: Mr Amico’s death from Metastatic Bladder Cancer was hastened and contributed to by multiple morphine overdoses between 10 and 11 June 2024 due to a prescription error that was not scrutinised. Morphine reversal and subsequent pain relief was not managed according to the guidelines and Mr Amico suffered acute withdrawal syndrome.
Medical cause of death of ‘1a Type 2 Respiratory Failure 1b Community Acquired Pneumonia, Inadvertent Morphine Overdoses and acute withdrawal syndrome 1c Metastatic Bladder Cancer with Advanced Clinical Frailty
Circumstances of the death
Paolino Amico had a history of metastatic bladder cancer that had not responded to treatment on a clinical trial. Mr Amico was discharged from hospital on 29 May 2024 and was oxygen dependent. Mr Amico developed severe bilateral pneumonia and was admitted into Princess Alexandra Hospital on 9 June 2024 and treated with antibiotics, nebulisers and fluids. Mr Amico was not seen in person by a doctor who altered his prescription in the emergency department on 10 June. On the afternoon of 10 June Mr Amico’s medication chart was not scrutinised when he had a medical review as he was deteriorating. Due to a prescription error Mr Amico received multiple overdoses of a controlled drug morphine sulphate (slow release) on 10 and 11 June 2024 resulting in morphine accumulation that was partially reversed with naloxone on 11 June. Mr Amico was not deemed suitable for admission to intensive care for Naloxone infusion. Mr Amico died on 12 June 2024 at Princess Alexandra Hospital as a consequence of Type 2 Respiratory Failure due to Community Acquired Pneumonia and Inadvertent Morphine Overdoses with Metastatic Bladder Cancer with Advanced Clinical Frailty.There was a delay in raising a medical emergency when Mr Amico had elevated NEWS score of 10 and his morphine reversal and pain relief was not managed according to the guidelines and he suffered acute withdrawal syndrome.
Coroner’s concerns
(1) The consultant required a discharge plan for oxygen therapy to be in place before Mr Amico could go home. The hospital discharge plan and medications were confusing and the referral for oxygen therapy requirement was unclear, and the PAT testing for the machine was out of date. Paramedics advised the family that the oxygen provided on Mr Amico’s discharge was low flow and was not meeting his oxygen requirements with his oxygen saturations at 68% and this immediately improved on ambulance crew equipment. (2) Mr Amico did not receive his prescribed medications during his second admissions when he was readmitted to hospital on 9 June. a. On 9 June a doctor in Accident & Emergency had reviewed Mr Amico’s prescribed medications and increased liquid oral morphine sulphate 10 mg in 5mL Solution 4 hourly as required with 2.5 -5 mg max 6 doses at 22:57 hours with slow released morphine sulphate (MST) continued 2 times daily. Trust staff did not administer any morphine to Mr Amico although he and his family were raising concerns about his high level of pain. b. The family was informed incorrectly that medications had not been prescribed. On the morning of 10 June, the family were given permission by a nurse to dispense from Mr Amico’s own supply of medications that he had brought to the hospital due to his level of pain. This was not accurately recorded in Mr Amico’s record. Mr Amico took his prescribed morning dose of MST. c. On 10 June the nurse in Accident & Emergency did not escalate to the nurse in charge or a senior doctor that she could not locate the doctor allocated to Mr Amico and instead approached a foundation year 1 doctor to prescribe pain relief for Mr Amico. The nurse informed the doctor who was junior and very busy that the frequency of the morphine needed to be increased for Mr Amico. The doctor did not escalate the matter and did not review Mr Amico before prescribing a controlled drug. d. Neither the nurse nor the doctor sufficiently scrutinised the medication prescribed on 9 June or on the Trust system that would have shown the correct medications. This led to a prescription error being made with MST being increased from 2 times daily to 4 times daily. Mr Amico was not referred for pain management. e. Mr Amico then moved to a ward. Multiple nurses were involved in checking and administering a controlled drug morphine sulphate slow release (MST) on 5 separate occasions between 10 and 11 June 2024 and did not raise concerns about the potential for a prescription error or note that Mr Amico had already received 1 dose of MST that morning. (3) Mr Amico’s NEWS score increased, and an emergency call was not put out on 11 June when it was established that Mr Amico was unresponsive even to pain from 03:00 hours . (4) The on-call doctor was called approximately one hour after Mr Amico’s NEWS score was found to be 10 and arrived at 07:50, this was not an emergency call. The on-call doctor had not been informed of: a. the deterioration in Mr Amico’s presentation during the night b. that the family had informed nursing staff of their concerns Mr Amico had been given the wrong medication when he was noted to be unresponsive at approximately 03:00 hours, that should have immediately raised concerns about an overdose of MST. (5) The on-call doctor escalated concerns immediately but not emergency call was put out. (6) Mr Amico morphine overdose was partially treated: a. There was an immediate response to Naloxone but the opioid reversal for overdose was not in accordance with British National Formulary guidelines or with an NHS England alert previously issued. b. There was no consideration or plan for alternative pain management in a patient who had been receiving morphine pain relief as part of his treatment plan for cancer. c. Mr Amico suffered acute withdrawal syndrome and family complained about his suffering to hospital staff that they stated was not ameliorated. An emergency call would have triggered the attendance of an Anaesthetist who could have given advice on opioid reversal in a palliative patient. Princess Alexandra Hospital & NHS England (7) Multiple nurses were involved in morphine administration and all had completed their original training outside of the UK and had undertaken a Trust medicines administration training that should have recognised that the prescription of MST 4 times a day was not appropriate. Mr Amico received 6 doses of MST in less than 24 hours instead of 2. (8) Medicines administration refresher training for nurses is not mandatory and the Trust in reviewing this case has not followed a local recommendation from senior nurses for this to be included.
Concerns and recipient responses
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Report evidence summary
Concerns raised19
Failure to provide clear oxygen-therapy discharge planning and referral information
Each statement is shown once, even when linked to more than one concern.
Actions described in response An action is something a recipient says it has done, is doing, or plans to do in response to a concern raised.10
Action
Operate networks for Controlled Drugs Accountable Officers and Medication Safety Officers to receive and spread learning from medication errors.
Stated byNHS EnglandStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Provide guidance and tools to NHS Trusts for learning from patient safety incidents and improving controlled-drug safety.
Stated byNHS EnglandStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Provide restorative clinical supervision and professional nurse advocate learning on controlled drugs, communication, challenge and escalation.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Review the training framework, including whether management training should become mandatory and whether refresher training should be tracked and monitored.
Stated bythe Princess Alexandra Hospital NHS TrustStated in progressThe respondent said that this action was in progress when they made their response on 19 November 2025.
Action
Share opioid reversal guidance through palliative-care educational events and hold collaborative opioid-learning events with the integrated care system.
Stated bythe Princess Alexandra Hospital NHS TrustStatus at responseThe respondent said that this action was partly complete when they made their response on 19 November 2025.
Action
Clarify morphine product names and predefine twice-daily frequency for modified-release morphine prescriptions in the electronic prescribing system.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Introduce a patients’ own controlled drug book in the emergency department to record and account for patients’ controlled medicines.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Review the Trust’s naloxone policy following the incident.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Remove the option to modify existing prescriptions in the electronic prescribing system, requiring cancellation or discontinuation and reordering with clinical warnings.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
Action
Include the emergency department escalation process in area-specific orientation for nurses redeployed from their base wards.
These actions and other statements could not be clearly connected to one concern in this report.
Recipient-stated actions An action is something a recipient says it has done, is doing, or plans to do in response to a concern raised.5
1
Discuss received Prevention of Future Deaths reports through the Regulation 28 Working Group and share key learning nationally and regionally across the NHS.
Stated byNHS EnglandStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
2
Hold monthly meetings between ward matrons, the chief pharmacist and EPMA lead to monitor medication incident themes.
Stated bythe Princess Alexandra Hospital NHS TrustStated in progressThe respondent said that this action was in progress when they made their response on 19 November 2025.
3
Conduct a multidisciplinary after-action review of the medication administration incident and identify learning and actions.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
4
Maintain mandatory Medical Gases training for staff requiring it, with completion recorded on staff training profiles.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.
5
Share medication-safety learning across divisions and Trustwide through governance meetings and the learning-from-deaths group.
Stated bythe Princess Alexandra Hospital NHS TrustStated completedThe respondent said that this action was complete when they made their response on 19 November 2025.